灵长类模型生殖/发育毒性和的研究现状的评价
来源： 浏览量：739 更新日期：2010年1月9日
Toxicology. 2003 Apr 1;185(3):221-7.
Reproductive/developmental toxicity and immunotoxicity assessment in the nonhuman primate model.
Buse E, Habermann G, Osterburg I, Korte R, Weinbauer GF.
Covance Laboratories GmbH, Kesselfeld 29, 48163 Munster, Germany.
Nonhuman primates are being used increasingly as a non-rodent animal model during preclinical toxicology and safety assessment on the basis of proven similarity and comparability between nonhuman primates and humans. The validity of the nonhuman primate models applies to many aspects of toxicological testing and holds particularly true for the evaluation of reproductive toxicology and developmental toxicology. More recently, the advent of humanized antibodies and vaccines imposed further demand on nonhuman primate models since many immunotherapeutics do not interact with rodent receptors but frequently only cross-react with primate tissue. In this paper we discuss the suitability of primate models for reproductive, developmental and immunotoxicology testing, and present our initial data on the development of lymphatic organs and immune system in a nonhuman primate model.